Hey Fredo,
though the crashes I had (and described in other threads) might not have something to do with those settings you mentioned I disabled those prefs today.
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Auto Hitpoints are disabled since a while (I do not need that, if I need hitpoints I can create them at any time)
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the suspend VST3 processing is a great feature and turning this off increased the CPU load of that 508 track project from about 55% to 80% - but I still have headroom… if I will need more juice in the final sessions (not all orchestration imported yet) I will re-activate it again because a project like that has a lot of “this track is only used in one part of that album” stuff…
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Asio Guard: I never was able to understand everything behind it, it seems to decrease my system load a little so I had it activated, now it is disables…
It seems to me that I have a better reacting system now and at least today I had no crashes (was avoiding all those critical actions though).
Those 3 prefs are great features and I do not have the impression that they are causing problems - but as you said - maybe I have less overall issues now when handling that large project.
P.S: Saving Time is still slow 
)