It is very possible that I am slightly misremembering the problem and that Auto-Tune was combining and saving all its edits in one file, the more edits the larger the file. If Auto-Tune, then other plug-ins could, possibly, do it too.
You could open that 50gbs audiofile and see what’s in it. (I am assuming that there is one 50gbs file, and not lots of little files, although I am not 100% that that is the case.) That file could be one audiofile repeated 20 times, for example. And by comparing some of those repeated segments, you might well be able to see what, if any, differences there are between the repeated sections and tell if they are in fact different, edited versions of the original audiofile.
You might want to look at the specific plug-ins which you’re using. (This would implicate only VST’s and not VSTi’s, obviously.)