My advice would be “leave the system clock alone” unless You really have DPC problems.
I have experimented with various HPET optimizations throughout Win XP, 7 and 10. Yes it’s an old hat 
It resurfaces with every new Windows version, especially in the gaming community.
And it might help on “your” exact motherboard, firmware and other hardware configuration. But from experience I would be cautious, it can give you other problems, like ghosting mouse cursor and other grafix problems, even blue screens.
On a well running PC it will give you nothing, it’s not an optimization, and should not be applied without thought.
I welcome the discussion, I have used a lot of time tweaking my computers through the years, that is until Windows 10 came along. Probably the first Windows OS that I really could leave alone and just enjoy, with hardly any optimization.
YMMV
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