With Win10 64bit I installed most of my programs on another (physical, SSD) drive than my boot drive C. On that drive Cubase (9, 64bit) program in a Cubase folder, and .VSTsound files in a separate folder.
Also all Cubase project files in another separate folder, AND plugins organized in a dedicated plugins-folder, internally divided in standalone versions, and DLLs in separate 32bit, 64bit and jBridged 32 - 64bit converted versions. Some escape during installation, and organize themselves in some VST2 or VST3 folder on the boot-drive alas.
While installing Cubase 8 etc, you can direct the installers, look for some advanced ‘click me’ button, go "back’ if you missed something like “browse”, and maybe install running as administrator to get more options. - F