Same problem here. Fresh windows 10 installation on pc, start nuendo 8 , when on exit it hangs.
No other special software installed only norton Internet Security, Halion 5 and the Steinberg mr816csx software and driver, Novation Remote mk 61 SL mk II driver ( No install of Automap software ), still trying to find the problem. With Nuendo 7 i did have the same problem, therefore honnestly speaking upgraded to version 8, with no good result