The OS and build that has audio dropouts.
Windows 10 Pro X64. - no MS patches
Nuendo 10
ASRock Fatal1ty X399
EVGA RTX 2080Ti
AMD RYZEN Threadripper 2990WX 32 Core
128GB DDR4 3600 Memory. GSkill Trident Z
RME HDSPe Madi-FX - latest drivers
RME HDSPe AES x 2 - latest driver
EVGA Supernova 1200 Platinum PSU
Custom loop water cooler